Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-RGS3 Antibody Picoband®

Boster Bio Anti-RGS3 Antibody catalog # PA2050. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

RGS3 (Regulator of G Protein Signaling 3), is a protein that in humans is encoded by the RGS3 gene. Chatterjee et al. (1997) studied RGS3, the largest member of the RGS family then identified. Mouse Pdz-Rgs3 can mediate signaling from the ephrin-B cytoplasmic tail. By radiation hybrid mapping, Chatterjee et al. (1997) assigned the RGS3 gene to chromosome 9q31-q33. Lu et al. (2001) showed that Sdf1, a chemokine with a G protein-coupled receptor, and Bdnf are chemoattractants for cerebellar granule cells, and that Sdf1 chemoattraction is selectively inhibited by soluble ephrin-B receptor. This inhibition could be blocked by a truncated Pdz-Rgs3 protein lacking the RGS domain.

Synonyms

Regulator of G-protein signaling 3; RGS3; C2PA; Rgs3

Gene Name

Rgs3

Gene ID

50780

UniProt

Q9DC04

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse RGS3, identical to the related rat sequence, and different from the related human sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newborn mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed. .

Applications

IHC, WB

Field of Research

G Protein Signaling, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. .

References & Citations

1. Chatterjee, T. K., Eapen, A., Kanis, A. B., Fisher, R. A. Genomic organization, 5-prime-flanking region, and chromosomal localization of the human RGS3 gene. Genomics 45: 429-433, 1997. 2. Druey, K. M., Blumer, K. J., Kang, V. H., Kehrl, J. H. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature 379: 742-746, 1996. 3. Lu, Q., Sun, E. E., Klein, R. S., Flanagan, J. G. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell 105: 69-79, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

106219 MW

Observed Molecular Weight

93 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Regulator of G-protein signaling 3

Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. The long isoforms are cytoplasmic.

Sequence Similarities

Contains 1 PDZ (DHR) domain.

Protein Name

Regulator of G-protein signaling 3

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Trypsin (PRSS3) (NM_007343) Human Over-expression Lysate
LH01303V 100 µg

Trypsin (PRSS3) (NM_007343) Human Over-expression Lysate

Ask
View Details
Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)
MBS1014795-01 0.02 mg (E-Coli)

Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)

Ask
View Details
Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)
MBS1014795-02 0.1 mg (E-Coli)

Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)

Ask
View Details
Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)
MBS1014795-03 0.02 mg (Yeast)

Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)

Ask
View Details
Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)
MBS1014795-04 0.1 mg (Yeast)

Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)

Ask
View Details
Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)
MBS1014795-05 0.02 mg (Baculovirus)

Recombinant Streptococcus agalactiae serotype V Translation initiation factor IF-3 (infC)

Ask
View Details