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Anti-Phosphoglycerate kinase 1 PGK1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

PGK1 (Phosphoglycerate Kinase 1), also known as PGKA, is an enzyme that in humans is encoded by the PGK1 gene. The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. And the encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.

Synonyms

Phosphoglycerate kinase 1;2.7.2.3; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2; PGK1; PGKA; MIG10, OK/SW-cl.110

Gene Name

PGK1

Gene ID

5230

UniProt

P00558

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human PGK1, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. .

Applications

Flow Cytometry

Field of Research

Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) .

References & Citations

1. Entrez Gene: PGK1 phosphoglycerate kinase 1. 2. Michelson AM, Markham AF, Orkin SH (May 1983) . Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase. Proc Natl Acad Sci U S A 80 (2) : 472–6. 3. Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985) . Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]. Gene 32 (3) : 409–17.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

44615 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Phosphoglycerate kinase 1

Subcellular Location

Cytoplasm.

Sequence Similarities

Belongs to the phosphoglycerate kinase family.

Protein Name

Phosphoglycerate kinase 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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