Anti-CETP Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
CETP (Cholesteryl Ester Transfer Protein Plasma), is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. CETP is also known as lipid transfer protein I (Day et al., 1994) . Sparkes et al. (1987) used a CETP probe against DNA from a human/mouse somatic cell hybrid panel to assign the CETP gene to chromosome 16. Because the role of CETP in atherosclerosis remained unclear, Okamoto et al. (2000) attempted to develop a potent, specific CETP inhibitor. One inhibitor, JTT-705, forms a disulfide bond with CETP and increases high density lipoprotein (HDL) cholesterol, decreases non-HDL cholesterol, and inhibits the progression of atherosclerosis in rabbits.
Synonyms
Cholesteryl ester transfer protein ; Lipid transfer protein I ; CETP
Gene Name
CETP
Gene ID
1071
UniProt
P11597
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CETP.
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma.
Applications
Flow Cytometry
Field of Research
Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641) . Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796) . .
References & Citations
1. Day, J. R., Albers, J. J., Lofton-Day, C. E., Gilbert, T. L., Ching, A. F. T., Grant, F. J., O'Hara, P. J., Marcovina, S. M., Adolphson, J. L. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. J. Biol. Chem. 269: 9388-9391, 1994. 2. Okamoto, H., Yonemori, F., Wakitani, K., Minowa, T., Maeda, K., Shinkai, H. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 406: 203-207, 2000. 3. Sparkes, R. S., Drayna, D., Mohandas, T., Klisak, I., Heinzmann, C., Lawn, R., Lusis, A. J. Assignment of cholesterol ester transfer protein (CETP) gene to human 16q21. (Abstract) Cytogenet. Cell Genet. 46: 696 only, 1987.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
54756 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Cholesteryl ester transfer protein
Subcellular Location
Secreted, extracellular space . Secreted in plasma. .
Sequence Similarities
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Protein Name
Cholesteryl ester transfer protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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