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Anti-TRAM1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TRAM1 (Translocation-Associating Membrane Protein 1), By crosslinking and reconstitution of canine proteoliposomes, followed by microsequencing and PCR screening of canine kidney and HeLa cell cDNA libraries, Gorlich et al. (1992) isolated cDNAs encoding TRAM (translocating chain-associating membrane protein) . The International Radiation Hybrid Mapping Consortium mapped the TRAM gene to chromosome 8. Sequence analysis predicted that human TRAM is a 374-amino acid, 8-pass transmembrane protein that shares 95% amino acid identity with the canine protein. Functional analysis indicated that TRAM influences glycosylation and is stimulatory or required for the translocation of secretory proteins.

Synonyms

Translocating chain-associated membrane protein 1; TRAM1; TRAM

Gene Name

TRAM1

Gene ID

23471

UniProt

Q15629

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TRAM1, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Organelle Proteins, Organelles, Protein Trafficking, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Stimulatory or required for the translocation of secretory proteins across the ER membrane.

References & Citations

1. Gorlich, D., Hartmann, E., Prehn, S., Rapoport, T. A. A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature 357: 47-52, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

43072 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Translocating chain-associated membrane protein 1

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the TRAM family.

Protein Name

Translocating chain-associated membrane protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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