Anti-Selenocysteine lyase SCLY Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
SCLY (Selenocysteine Lyase), is an enzyme that catalyzes the chemical reaction. This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The International Radiation Hybrid Mapping Consortium mapped the human SCLY gene to chromosome 2. Mihara et al. (2000) showed that mouse Scly catalyzed the conversion of L-selenocysteine to L-alanine. Scly activity required pyridoxal 5-prime phosphate, was specific to L-selenocysteine, and showed maximum reactivity at pH 9.0.
Synonyms
Selenocysteine lyase; hSCL;4.4.1.16; SCLY; SCL
Gene Name
SCLY
Gene ID
51540
UniProt
Q96I15
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SCLY.
Clonality
Polyclonal
Tissue Specificity
Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. .
Applications
Flow Cytometry
Field of Research
Amino Acid Metabolism, Amino Acids, Cofactors, Vitamins/Minerals, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium. .
References & Citations
1. Mihara, H., Kurihara, T., Watanabe, T., Yoshimura, T., Esaki, N. cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase: candidate for selenium delivery protein in selenoprotein synthesis. J. Biol. Chem. 275: 6195-6200, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
48149 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Selenocysteine lyase
Subcellular Location
Cytoplasm, cytosol .
Sequence Similarities
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Protein Name
Selenocysteine lyase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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