Anti-Nucleoplasmin-2 NPM2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
NPM2 (Nucleophosmin/Nucleoplasmin Family Member 2), Burns et al. (2003) mapped the mouse Npm2 gene to chromosome 14. Burns et al. (2003) found that female Npm2-null mice showed defects in preimplantation embryo development, with abnormalities in oocyte and early embryonic nuclei.
Synonyms
Nucleoplasmin-2; NPM2
Gene Name
NPM2
Gene ID
10361
UniProt
Q86SE8
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human NPM2.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cell Type Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. .
References & Citations
1. Burns, K. H., Viveiros, M. M., Ren, Y., Wang, P., DeMayo, F. J., Frail, D. E., Eppig, J. J., Matzuk, M. M. Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science 300: 633-636, 2003.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
24152 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Nucleoplasmin-2
Subcellular Location
Nucleus . Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm. .
Protein Name
Nucleoplasmin-2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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