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Anti-Neurosecretory protein VGF VGF Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

VGF (VGF, Nerve Growth Factor-Inducible), is a protein and neuropeptide that may play a role in regulating energy homeostasis, metabolism. Canu et al. (1997) noted that rat Vgf encodes a predicted 70-kD polypeptide that shares similarities with the secretogranin/chromogranin family and is found in the secretory granules of subsets of neurons and endocrine cells. By fluorescence in situ hybridization, Canu et al. (1997) assigned the VGF gene to 7q22. Canu et al. (1997) demonstrated that the single-copy human VGF gene spans 6 kb of genomic DNA and contains 2 exons. The entire VGF protein is encoded by exon 2, while exon 1 contains only 5-prime untranslated sequence. The structural organization of the human gene is similar to that described for the rat VGF gene (Salton et al., 1991), and both the translated and the untranslated regions show a high degree of sequence homology to the rat gene.

Synonyms

Neurosecretory protein VGF; Neuroendocrine regulatory peptide-1; NERP-1; Neuroendocrine regulatory peptide-2; NERP-2; Antimicrobial peptide VGF[554-577]; VGF

Gene Name

VGF

Gene ID

7425

UniProt

O15240

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human VGF, different from the related rat and mouse sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. .

Applications

Flow Cytometry

Field of Research

Endocrine System, Growth Factors/Hormones, Neurology Process, Neuroscience, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. .

References & Citations

1. Canu, N., Possenti, R., Ricco, A. S., Rocchi, M., Levi, A. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. Genomics 45: 443-446, 1997. 2. Hunsberger, J. G., Newton, S. S., Bennett, A. H., Duman, C. H., Russell, D. S., Salton, S. R., Duman, R. S. Antidepressant actions of the exercise-regulated gene VGF. Nature Med. 13: 1476-1482, 2007. 3. Salton, S. R. J., Fischberg, D. J., Dong, K. W. Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Molec. Cell. Biol. 11: 2335-2349, 1991.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67258 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Neurosecretory protein VGF

Subcellular Location

Secreted . Cytoplasmic vesicle, secretory vesicle . Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Sequence Similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein Name

Neurosecretory protein VGF

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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