Anti-VRL1/TRPV2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2), also known as VRL1, is a protein that, in humans, is encoded by the TRPV1 gene. The International Radiation Hybrid Mapping Consortium mapped the TRPV2 gene to chromosome 17. This gene encodes an ion channel that is activated by high temperatures above 52??C. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is though that in other tissues the channel may be activated by stimuli other than heat.

Synonyms

Transient receptor potential cation channel subfamily V member 2; TrpV2; Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1; TRPV2; VRL

Gene Name

TRPV2

Gene ID

51393

UniProt

Q9Y5S1

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human VRL1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

Applications

Flow Cytometry

Field of Research

Cancer, DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, p53 Pathway, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. .

References & Citations

1. Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398: 436-441, 1999. 2. Iwata, Y., Katanosaka, Y., Arai, Y., Shigekawa, M., Wakabayashi, S. Dominant-negative inhibition of Ca (2+) influx via TRPV2 ameliorates muscular dystrophy in animal models. Hum. Molec. Genet. 18: 824-834, 2009.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

85981 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Transient receptor potential cation channel subfamily V member 2

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Cytoplasm . Melanosome . Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.

Protein Name

Transient receptor potential cation channel subfamily V member 2

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-VRL1/TRPV2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

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