Anti-LTBR Antibody Picoband®

LTBR (Lymphotoxin B Receptor), also called TNFCR or LT-BETA-R, is a receptor for lymphotoxin which in humans is encoded by the LTBR gene. By linkage analysis with recombinant inbred mouse strains, Nakamura et al. (1995) demonstrated that the Tnfcr locus is close to the Tnfr1 gene on mouse chromosome 6. Presumably, the human homolog is located on 12p13. Silva-Santos et al. (2005) reported that double-positive T cells regulate the differentiation of early thymocyte progenitors and gamma-delta cells by a mechanism dependent on the transcription factor ROR-gamma-t and the lymphotoxin-beta receptor. Lo et al. (2007) identified lymphotoxin and LIGHT (TNFSF14), tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators of key enzymes that control lipid metabolism.

Tumor necrosis factor receptor superfamily member 3; Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III; LTBR; D12S370, TNFCR, TNFR3, TNFRSF3

Apoptosis, Associated Proteins, Cell Biology, Epigenetics and Nuclear Signaling, Growth Factors/Hormones, Intracellular, NFKB Pathway, Nuclear Signaling Pathways, Signal Transduction

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. .

1. Lo, J. C., Wang, Y., Tumanov, A. V., Bamji, M., Yao, Z., Reardon, C. A., Getz, G. S., Fu, Y.-X. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316: 285-288, 2007. 2. Nakamura, T., Tashiro, K., Nazarea, M., Nakano, T., Sasayama, S., Honjo, T. The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping. Genomics 30: 312-319, 1995. 3. Silva-Santos, B., Pennington, D. J., Hayday, A. C. Lymphotoxin-mediated regulation of gamma-delta cell differentiation by alpha-beta T cell progenitors. Science 307: 925-928, 2005.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.