What sizes are available for Anti-Toll-like receptor 10 TLR10 Antibody Picoband® Fluoro647 Conjugated?

Anti-Toll-like receptor 10 TLR10 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

Anti-Toll-like receptor 10 TLR10 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-Toll-like receptor 10 TLR10 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-Toll-like receptor 10 TLR10 Antibody Picoband® Fluoro647 Conjugated is PA1958-Fluoro647.

Selected Variant

PA1958-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

TLR10 (Toll-like receptor 10), is a protein that in humans is encoded by the TLR10 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. By genomic sequence analysis, Hasan et al. (2005) determined that the TLR10 gene is clustered with TLR1 and TLR6 on chromosome 4p14. By coimmunoprecipitation analysis, Hasan et al. (2005) found that TLR10 associated with itself and with TLR1 and TLR2, but not with MD2. Signaling studies showed that TLR10 required MYD88, but not TIRAP, TRAM (TICAM2), or TRIF (TICAM1), to activate immune system promoters. Pro674 within the TLR10 TIR domain was required to activate all promoter examined.

Synonyms

Toll-like receptor 10; CD290; TLR10; UNQ315/PRO358

Gene Name

TLR10

Gene ID

81793

UniProt

Q9BXR5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TLR10.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology, Innate Immunity, Macrophage/Inflammation, Receptors, TLR Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity) . .

References & Citations

1. Chuang, T.-H., Ulevitch, R. J. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 1518: 157-161, 2001. 2. Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Briere, F., Vlach, J., Lebecque, S., Trinchieri, G., Bates, E. E. M. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immun. 174: 2942-2950, 2005. 3. Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., Liu, Y.-J. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194: 863-869, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

94564 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Toll-like receptor 10

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Sequence Similarities

Belongs to the Toll-like receptor family.

Protein Name

Toll-like receptor 10

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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