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Anti-MALT1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1), also called MLT or PARACASPASE, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al. (1999) and Akagi et al. (1999) mapped the MALT1 gene to chromosome 18q21. Using mouse models, Ruland et al. (2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B (NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases.

Synonyms

Mucosa-associated lymphoid tissue lymphoma translocation protein 1;3.4.22.-; MALT lymphoma-associated translocation; Paracaspase; MALT1; MLT

Gene Name

MALT1

Gene ID

10892

UniProt

Q9UDY8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MALT1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Applications

Flow Cytometry

Field of Research

Apoptosis, Caspases, Cell Biology, Intracellular, NFKB Pathway, Nuclear Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. .

References & Citations

1. Akagi, T., Motegi, M., Tamura, A., Suzuki, R., Hosokawa, Y., Suzuki, H., Ota, H., Nakamura, S., Morishima, Y., Taniwaki, M., Seto, M. A novel gene, MALT1 at 18q21, is involved in t (11;18) (q21; q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene 18: 5785-5794, 1999. 2. Dierlamm, J., Baens, M., Wlodarska, I., Stefanova-Ouzounova, M., Hernandez, J. M., Hossfeld, D. K., De Wolf-Peeters, C., Hagemeijer, A., Van den Berghe, H., Marynen, P. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t (11;18) (q21; q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 93: 3601-3609, 1999. 3. Ruland, J., Duncan, G. S., Wakeham, A., Mak, T. W. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19: 749-758, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

92 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Subcellular Location

Cytoplasm, perinuclear region . Nucleus . Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.

Sequence Similarities

Belongs to the peptidase C14B family.

Protein Name

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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