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Anti-TXNRD2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TXNRD2 (Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are selenocysteine (sec) -containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing power of NADPH. By STS analysis and genomic sequence analysis, respectively, Miranda-Vizuete et al. (1999) and Sun et al. (1999) mapped the TXNRD2 gene to chromosome 22q11.2. Miranda-Vizuete et al. (1999) mapped the mouse gene to chromosome 16. Gasdaska et al. (1999) showed that TXNRD2 was a thioredoxin reductase that could ly reduce proteins such as insulin.

Synonyms

Thioredoxin reductase 2, mitochondrial;1.8.1.9; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3; TXNRD2; KIAA1652, TRXR2

Gene Name

TXNRD2

Gene ID

10587

UniProt

Q9NNW7

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TXNRD2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism

Purification

Immunogen affinity purified.

Form

Liquid

Function

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.

References & Citations

1. Gasdaska, P. Y., Berggren, M. M., Berry, M. J., Powis, G.Cloning, sequencing, and functional expression of a novel human thioredoxin reductase.FEBS Lett. 442: 105-111, 1999. 2. Miranda-Vizuete, A., Damdimopoulos, A. E., Pedrajas, J. R., Gustafsson, J.-A., Spyrou, G.Human mitochondrial thioredoxin reductase: cDNA cloning, expression, and genomic organization.Europ. J. Biochem. 261: 405-412, 1999. 3. Sun, Q.-A., Wu, Y., Zappacosta, F., Jeang, K.-T., Lee, B. J., Hatfield, D. L., Gladyshev, V. N.Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.J. Biol. Chem. 274: 24522-24530, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

56507 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Thioredoxin reductase 2, mitochondrial

Subcellular Location

Mitochondrion .

Sequence Similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Protein Name

Thioredoxin reductase 2, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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