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Anti-Krueppel-like factor 5 KLF5 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Reporter gene

Synonyms

Krueppel-like factor 5; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-box-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2; KLF5; BTEB2, CKLF, IKLF

Gene Name

KLF5

Gene ID

688

UniProt

Q13887

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human KLF5, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed only in testis and placenta.

Applications

Flow Cytometry

Field of Research

Apoptosis, Cancer, Cancer Susceptibility, Cardiovascular, Cell Biology, Domain Families, Epigenetics and Nuclear Signaling, Hypertrophy, Intracellular, Krueppel Like Factor, Mesenchymal Stem Cells, Oncoproteins, Oncoproteins/Suppressors, p53 Pathway, Proto-Oncogenes, Stem Cells, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

References & Citations

1. Oishi, Y., Manabe, I., Tobe, K., Tsushima, K., Shindo, T., Fujiu, K., Nishimura, G., Maemura, K., Yamauchi, T., Kubota, N., Suzuki, R., Kitamura, T., Akira, S., Kadowaki, T., Nagai, R.Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.Cell Metab. 1: 27-39, 2005. 2. Shindo, T., Manabe, I., Fukushima, Y., Tobe, K., Aizawa, K., Miyamoto, S., Kawai-Kowase, K., Moriyama, N., Imai, Y., Kawakami, H., Nishimatsu, H., Ishikawa, T., and 10 others.Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.Nature Med. 8: 856-863, 2002. 3. Sogawa, K., Imataka, H., Yamasaki, Y., Kusume, H., Abe, H., Fujii-Kuriyama, Y.cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.Nucleic Acids Res. 21: 1527-1532, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50792 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Krueppel-like factor 5

Subcellular Location

Nucleus .

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein Name

Krueppel-like factor 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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