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Anti-Transcription factor Sp4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

SP4 (Sp4 transcription factor), also known as Transcription factor Sp4, MGC130008, MGC130009, SPR-1, HF1B,   is a  protein  that in humans is encoded by the  SP4  gene. It is a multigene family of SP proteins. Northern blot analysis that SP4 is abundantly expressed as a 7.5-kb message in brain, but barely detectable in other human cell lines. SP4 is an activator protein like SP1. However, in contrast to SP1, SP4 is not able to act synergistically through adjacent binding sites.

Synonyms

Transcription factor Sp4; SPR-1; SP4

Gene Name

SP4

Gene ID

6671

UniProt

Q02446

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SP4, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Abundant in brain.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

References & Citations

1. Hagen, G., Muller, S., Beato, M., Suske, G. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 20: 5519-5525, 1992. 2. Hagen, G., Dennig, J., Preiss, M., Beato, M., Suske, G.Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J. Biol. Chem. 270: 24989-24994, 1995.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

81985 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Transcription factor Sp4

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein Name

Transcription factor Sp4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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