Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PTCH2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for  Ptch2  in adult epidermal homeostasis via Shh signaling.

Synonyms

Protein patched homolog 2; PTC2; PTCH2; UNQ560/PRO1121/PRO57079

Gene Name

PTCH2

Gene ID

8643

UniProt

Q9Y6C5

Host

Rabbit

Reactivity

Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. .

Applications

Flow Cytometry

Field of Research

Signaling Pathways, Stem Cells, Surface Molecules

Purification

Immunogen affinity purified.

Form

Liquid

Function

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) .

References & Citations

1. Nieuwenhuis, E., Motoyama, J., Barnfield, P. C., Yoshikawa, Y., Zhang, X., Mo, R., Crackower, M. A., Hui, C. Mice with a targeted mutation of Patched 2 are viable but develop alopecia and epidermal hyperplasia. Molec. Cell. Biol. 26: 6609-6622, 2006.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1859-Fluoro488

Calculated Molecular Weight

130544 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Protein patched homolog 2

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the patched family.

Protein Name

Protein patched homolog 2 (PTC2)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Saline Tryptone / Tryptophan Medium
GTR09886459 500 g

Saline Tryptone / Tryptophan Medium

Ask
View Details
Mouse Monoclonal SerpinB2 Antibody (930109) [Janelia Fluor 635]
FAB8550JF635 0.1 mL

Mouse Monoclonal SerpinB2 Antibody (930109) [Janelia Fluor 635]

Ask
View Details
Rabbit Polyclonal Patched Domain Containing 2 Antibody
NBP2-81757 0.1 mg

Rabbit Polyclonal Patched Domain Containing 2 Antibody

Ask
View Details
PRSS23 Antibody (Center)
E45M07356G-1 100 µL

PRSS23 Antibody (Center)

Ask
View Details