Anti-Fatty Acid Binding Protein 5/FABP5 Antibody Picoband®

FABP5 (fatty acid binding protein 5 (psoriasis-associated) ) is a protein  that in humans is encoded by the  FABP5 gene, also known as PAFABP, EFABP, E-FABP, KFABP, PA-FABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog. It is a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. The PAFABP cDNA encodes a 135-amino acid protein with molecular weight 15,164. This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in  psoriasis  tissue. It is though that FABPs roles include fatty acid uptake, transport, and metabolism. Kaczocha et al. (2009) identified  FABP5  and FABP7 as cytosolic proteins that transport AEA from the plasma membrane to subcellular fatty acid amide hydrolase, where it is hydrolyzed and inactivated. FABP3 did not show this specific transport function.

Fatty acid-binding protein, epidermal; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein 5; Keratinocyte lipid-binding protein; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; Fabp5; Fabpe, Klbp, Mal1

A synthetic peptide corresponding to a sequence at the N-terminus of mouse Fatty Acid Binding Protein 5, different from the related rat sequence by two amino acids.

Most abundant in keratinocytes and also in stratified epithelia of epidermis and tongue. Relatively high levels found in adipose and mammary tissues and small amounts found in heart, brain, liver, spleen, muscle and lung.

1. Kaczocha, M., Glaser, S. T., Deutsch, D. G.Identification of intracellular carriers for the endocannabinoid anandamide. Proc. Nat. Acad. Sci. 106: 6375-6380, 2009. 2. Madsen, P., Rasmussen, H. H., Leffers, H., Honore, B., Celis, J. E. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J. Invest. Derm. 99: 299-305, 1992.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.