Anti-SDHC Antibody Picoband®

SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) also known as SDH3, SUCCINATE DEHYDROGENASE CYTOCHROME b. The  SDHC  gene contains 6 exons. Oostveen et al. (1995)   found that in fact it was protein from the bovine SDH3 gene (encoding 1 of the 2 integral membrane proteins) that complemented the hamster mutation. The authors localized the human SDH3 gene to the short arm of chromosome one, within 1 to 2 Mb from the centromere.  Additionally, the authors stated that Southern analyses of human genomic DNA suggested that there are multiple SDH3 genes or pseudogenes. Elbehti-Green et al. (1998)   confirmed the assignment of the  SDHC  gene to 1q21 by FISH. Baysal et al. (2004)   described a family with PGL3 in which an 8,372-bp deletion in the  SDHC  gene was transmitted both maternally and paternally, without evidence of genomic imprinting.&nbsp

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL; SDHC; CYB560, SDH3

A synthetic peptide corresponding to a sequence at the N-terminus of human SDHC, different from the related mouse and rat sequences by three amino acids.

Cancer Susceptibility, Cell Biology, Developmental Biology, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Mitochondria, Mitochondrial Metabolism, Organelles, Oxidative Phosphorylation, Oxidative Stress, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers, Transcription, Tumor Suppressors

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) .

1. Baysal, B. E., Willett-Brozick, J. E., Filho, P. A. A., Lawrence, E. C., Myers, E. N., Ferrell, R. E. An Alu-mediated partial SDHC deletion causes familial and sporadic paraganglioma. J. Med. Genet. 41: 703-709, 2004. 2. Elbehti-Green, A., Au, H. C., Mascarello, J. T., Ream-Robinson, D., Scheffler, I. E. Characterization of the human SDHC gene encoding one of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria. Gene 213: 133-140, 1998. 3. Oostveen, F. G., Au, H. C., Meijer, P.-J., Scheffler, I. E. A Chinese hamster mutant cell line with a defect in the integral membrane protein C (II-3) of complex II of the mitochondrial electron transport chain. J. Biol. Chem. 270: 26104-26108, 1995.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.