Anti-Kallikrein 10/KLK10 Antibody Picoband®

KLK10 (kallikrein-related peptidase 10) also known as kallikrein 10, PRSSL1 or NES1, belongs to the kallikrein subfamily of serine proteases, which are involved in a variety of enzymatic processes. Its encoded protein is secreted and may play a role in suppression of tumorigenesis  in  breast  and  prostate cancers.KLK10  also contains 12 conserved cysteines in its protease domain that are expected to form 6 disulfide bonds, as in other serine proteases.  RT-PCR detected variable levels of  KLK10  expression in nearly all of the 35 adult and fetal tissues examined. The  KLK10  gene contains 6 exons, the first of which is noncoding. By fluorescence in situ hybridization,   Polikoff et al. (1997)   mapped the PRSSL1 gene to 19q13.3. By genomic sequence analysis,   Gan et al. (2000)   mapped the  KLK10  gene within the KLK gene cluster on chromosome 19q13. This cluster includes 13 KLK genes and 5 pseudogenes.

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

1. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006. 2. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130, 2000. 3. Polikoff, D., Kuo, W.-L., Cochran, J. F., Wernick, M., Kowbel, D., Myambo, K., Collins, C. C. Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping. Cytogenet. Cell Genet. 79: 147-148, 1997.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.