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Anti-HSPA2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

HSPA2 (heat shock 70kDa protein 2) also known as HEAT-SHOCK PROTEIN, 70-KD, 2, HSP70-2, HEAT-SHOCK PROTEIN, 70-KD, 3 or HSP70-3. Analysis of the sequence indicated that  HSPA2  is the human homolog of the murine Hsp70-2 gene, with 91.7% identity in the nucleotide coding sequence and 98.2% in the corresponding amino acid sequence.HSPA2  has less amino acid homology to the other members of the human HSP70 gene family.  HSPA2  is constitutively expressed in most tissues, with very high levels in testis and skeletal muscle. The  HSPA2  gene is located on chromosome 14q22-q24. Immunohistochemical analysis detected weak expression of  HSPA2  in spermatocytes and stronger expression in spermatids and in the tail of mature sperm. HSPA2  may be critical to sperm maturation through its role as a protein chaperone.

Synonyms

Heat shock-related 70 kDa protein 2; Heat shock 70 kDa protein 2; HSPA2

Gene Name

HSPA2

Gene ID

3306

UniProt

P54652

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human HSPA2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

HSPA1B is testis-specific.

Applications

Flow Cytometry

Field of Research

Cancer, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.

References & Citations

1. Bonnycastle, L. L. C., Yu, C.-E., Hunt, C. R., Trask, B. J., Clancy, K. P., Weber, J. L., Patterson, D., Schellenberg, G. D. Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2) . Genomics 23: 85-93, 1994. 2. Dix, D. J., Allen, J. W., Collins, B. W., Mori, C., Nakamura, N., Poorman-Allen, P., Goulding, E. H., Eddy, E. M. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc. Nat. Acad. Sci. 93: 3264-3268, 1996. 3. Hunt, C. R., Gasser, D. L., Chaplin, D. D., Pierce, J. C., Kozak, C. A. Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t and Grp78. Genomics 16: 193-198, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

70021 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Heat shock-related 70 kDa protein 2

Subcellular Location

Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Sequence Similarities

Belongs to the heat shock protein 70 family.

Protein Name

Heat shock-related 70 kDa protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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