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Anti-TFPI Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TFPI (Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa) . While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

Synonyms

Tissue factor pathway inhibitor; TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI; TFPI; LACI, TFPI1

Gene Name

TFPI

Gene ID

7035

UniProt

P10646

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TFPI.

Clonality

Polyclonal

Tissue Specificity

Mostly in endothelial cells.

Applications

Flow Cytometry

Field of Research

Cardiovascular, Platelets

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits factor X (X (a) ) ly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

References & Citations

1. Enjyoji, K.-I., Emi, M., Mukai, T., Imada, M., Leppert, M. L., Lalouel, J. M., Kato, H.Human tissue factor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of chromosome 2q.Genomics 17: 423-428, 1993. 2. Kleesiek, K., Schmidt, M., Gotting, C., Brinkmann, T., Prohaska, W.A first mutation in the human tissue factor pathway inhibitor gene encoding (P151L) TFPI. (Letter) Blood 92: 3976-3977, 1998. 3. Lupu, C., Zhu, H., Popescu, N. I., Wren, J. D., Lupu, F.Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.Blood 118: 4463-4471, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

35015 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tissue factor pathway inhibitor

Subcellular Location

Isoform Alpha: Secreted.

Sequence Similarities

Contains 3 BPTI/Kunitz inhibitor domains.

Protein Name

Tissue factor pathway inhibitor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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