Anti-Aryl hydrocarbon Receptor/AHR Antibody Picoband®

AHR (aryl hydrocarbon receptor), also called bHLHe76,   is a member of the family of  basic helix-loop-helix  transcription factors.  AhR is a cytosolic transcription factor that is normally inactive, bound to several  co-chaperones. The AHR gene is mapped on 7p21.1. Estrogenic actions of  AHR  agonists were detected in wildtype ovariectomized mouse uteri, but were absent in  Ahr  -/- or Er-alpha -/- ovariectomized mice. Complex assembly and ubiquitin ligase activity of CUL4B (AHR) in vitro and in vivo are dependent on the  AHR  ligand. In the CUL4B (AHR) complex, ligand-activated  AHR  acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation.  Cd4-positive cells from mice lacking  Ahr  developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development. Activation of  Ahr  during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in  Ahr  -/- mice. The TDO-AHR  pathway is active in human brain tumors and is associated with malignant progression and poor survival.  Ahr  activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. .

1. Andersson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M. L., Pettersson, S., Hanberg, A., Poellinger, L. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc. Nat. Acad. Sci. 99: 9990-9995, 2002. 2. Ema, M., Matsushita, N., Sogawa, K., Ariyama, T., Inazawa, J., Nemoto, T., Ota, M., Oshimura, M., Fujii-Kuriyama, Y. Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21. J. Biochem. 116: 845-851, 1994. 3. Le Beau, M. M., Carver, L. A., Espinosa, R., III, Schmidt, J. V., Bradfield, C. A. Chromosomal localization of the human AHR locus encoding the structural gene for the Ah receptor to 7p21-p15. Cytogenet. Cell Genet. 66: 172-176, 1994.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.