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Anti-Vinculin/VCL Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Synonyms

Vinculin; Metavinculin; MV; VCL

Gene Name

VCL

Gene ID

7414

UniProt

P18206

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Vinculin, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Metavinculin is muscle-specific.

Applications

Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cardiovascular, Contractility, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Actin filament (F-actin) -binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. .

References & Citations

1. Ezzell RM, Goldmann WH, Wang N, Parashurama N, Parasharama N, Ingber DE (1997) . Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton. Exp. Cell Res. 231 (1) : 14–26. 2. Goldmann WH, Ingber DE (2001) . Intact vinculin protein is Require for control of cell shape, cell mechanics, and rac-Dependent Lamellipodia Formation. Biochemical and Biophysical Research Communications. 290 (2) : 749–755. 3. Xu W, Baribault H, Adamson ED (1998) . vinculin knockout results in heart and brain defects during embryonic development. Development. 125 (2) : 327–337.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

123799 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Vinculin

Subcellular Location

Cytoplasm, cytoskeleton . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, focal adhesion . Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity) . Colocalizes with LIMD1 in the focal adhesions. .

Sequence Similarities

Belongs to the vinculin/alpha-catenin family.

Protein Name

Vinculin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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