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Anti-TRPC6 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .

Synonyms

Short transient receptor potential channel 6; TrpC6; Transient receptor protein 6; TRP-6; TRPC6; TRP6

Gene Name

TRPC6

Gene ID

7225

UniProt

Q9Y210

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human TRPC6, different from the related rat and mouse sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. .

Applications

Flow Cytometry

Field of Research

Calcium Channels, Calcium Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

References & Citations

1. D'Esposito, M., Strazzullo, M., Cuccurese, M., Spalluto, C., Rocchi, M., D'Urso, M., Ciccodicola, A. Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-q22. Cytogenet. Cell Genet. 83: 46-47, 1998. 2. Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., Schultz, G. activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259-263, 1999. 3. Kwon, Y., Hofmann, T., Montell, C. Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Molec. Cell 25: 491-503, 2007.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

106326 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Short transient receptor potential channel 6

Subcellular Location

Membrane ; Multi-pass membrane protein .

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.

Protein Name

Short transient receptor potential channel 6 (TrpC6)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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