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Anti-TRPC3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3; TRPC3; TRP3

Gene Name

TRPC3

Gene ID

7222

UniProt

Q13507

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TRPC3, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Applications

Flow Cytometry

Field of Research

Calcium Channels, Calcium Signaling, Cardiovascular, Hypertrophy, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vasculature

Purification

Immunogen affinity purified.

Form

Liquid

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. .

References & Citations

1. Fusco FR, Martorana A, Giampà C, De March Z, Vacca F, Tozzi A, Longone P, Piccirilli S, Paolucci S, Sancesario G, Mercuri NB, Bernardi G (July 2004) . Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes. Neuroscience Letters. 365 (2) : 137–42. 2. Li HS, Xu XZ, Montell C (1999) . Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron. 24 (1) : 261–73. 3. Zhou FW, Matta SG, Zhou FM (January 2008) . Constitutively active TRPC3 channels regulate basal ganglia output neurons. The Journal of Neuroscience. 28 (2) : 473–82.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

96009 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Short transient receptor potential channel 3

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.

Protein Name

Short transient receptor potential channel 3 (TrpC3)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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