Anti-CD62P/SELP Antibody Picoband® Fluoro488 Conjugated

P-Selectin, also called CD62, GRMP, GMP140 is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. The P-Selectin gene is mapped on 1q24.2. P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. In quiescent platelet, P-selectin is located on the inner wall of alpha-granules. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and suggested that SNX17 may function in the intracellular trafficking of P-selectin. P-selectin expression was found to be significantly and positively correlated with carotid artery stiffness and wall thickness, and the percentage of P-selectin-positive platelets was significantly higher in patients with carotid plaque.

P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P; SELP; GMRP, GRMP

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Adaptive Immunity, Angiogenesis, Atherosclerosis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Hematopoietic Progenitors, Immunology, Myeloid, Platelets, Stem Cells, Vascular Inflammation

Ca (2+) -dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. .

1. Burger, P. C., Wagner, D. D. Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101: 2661-2666, 2003. 2. Florian, V., Schluter, T., Bohnensack, R. A new member of the sorting nexin family interacts with the C-terminus of P-selectin. Biochem. Biophys. Res. Commun. 281: 1045-1050, 2001. 3. Hillis, G. S., Terregino, C., Taggart, P., Killian, A., Zhao, N., Dalsey, W. C., Mangione, A.Elevated soluble P-selectin levels are associated with an increased risk of early adverse effects in patients with presumed myocardial ischemia. Am. Heart J. 143: 235-241, 2002.