Anti-Interleukin-13 IL13 Antibody Picoband®
Anti-Interleukin-13
Product Specifications
Background
IL-13, Interleukin 13, is a protein that in humans is encoded by the IL-13 gene. IL-13 is cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. The IL-13 gene is mapped to 5q23-q31. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Ralpha) and at least one of two known IL-13-specific binding chains. IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function.
Synonyms
Interleukin-13; IL-13; IL13; NC30
Gene Name
IL13
Gene ID
3596
UniProt
P35225
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human IL-13.
Clonality
Polyclonal
Applications
WB
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Form
Lyophilized
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Function
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
References & Citations
1. Blackburn, M. R., Lee, C. G., Young, H. W. J., Zhu, Z., Chunn, J. L., Kang, M. J., Banerjee, S. K., Elias, J. A.Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. 2. Paul, W. E.Personal Communication.Bethesda, Md. 3/6/1993. 3. Punnonen, J., Aversa, G., Cocks, B. G., McKenzie, A. N. J., Menon, S., Zurawski, G., de Waal Malefyt, R., de Vries, J. E.Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.Proc. Nat. Acad. Sci. 90: 3730-3734, 1993.
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
15816 MW
Observed Molecular Weight
58 kDa
Specificity
No cross reactivity with other proteins.
Gene Name Synonym
Interleukin-13
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the IL-4/IL-13 family.
Protein Name
Interleukin-13 (IL-13)
Isotype
Rabbit IgG
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400050-500 1x 500 µL
IgA Secretory Component (SC05), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680352-500 1x 500 µL
CD31 / PECAM-1 (158-2B3), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401537-100 1x 100 µL
Beta-2 Microglobulin (Renal Failure &Tumor Marker) (rB2M/961), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details