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Anti-Somatostatin Receptor 1/SSTR1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

SSTR1 (Somatostatin receptor type 1) is a protein that in humans is encoded by the SSTR1 gene. The SSTR1 gene is mapped to chromosome 14. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.

Synonyms

Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SRIF-2; SSTR1

Gene Name

SSTR1

Gene ID

6751

UniProt

P30872

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Somatostatin Receptor 1, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Applications

Flow Cytometry

Field of Research

More Gpcr, Neurology Process, Neuropeptides, Neuroscience, Neurotransmission, Neurotransmitter, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na (+) /H (+) exchanger via pertussis toxin insensitive G proteins.

References & Citations

1. Kubota, A., Yamada, Y., Kagimoto, S., Shimatsu, A., Imamura, M., Tsuda, K., Imura, H., Seino, S., Seino, Y.Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors.J. Clin. Invest. 93: 1321-1325, 1994. 2. Yamada, Y., Post, S. R., Wang, K., Tager, H. S., Bell, G. I., Seino, S.Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.Proc. Nat. Acad. Sci. 89: 251-255, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

42686 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Somatostatin receptor type 1

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the transcription factor STAT family.

Protein Name

Somatostatin receptor type 1 (SS-1-R/SS1-R/SS1R)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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