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Anti-STAT4 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

STAT4 is a human gene. The protein encoded by this gene is a member of the STAT protein family of transcription factors. STAT4 is mapped to chromosome 2q32.2-q32.3 by fluorescence in situ hybridization. STAT4 is phosphorylated in response to interleukin-12 and is essential for IL12 signal transduction. Transactivation, electrophoretic mobility shift, and RNA interference analyses showed that Ikaros bound to the STAT4 promoter and was involved in regulation of STAT4 in human T cells.

Synonyms

Signal transducer and activator of transcription 4; STAT4

Gene Name

STAT4

Gene ID

6775

UniProt

Q14765

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human STAT4, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cancer, Epigenetics and Nuclear Signaling, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

References & Citations

1. Frucht, D. M., Aringer, M., Galon, J., Danning, C., Brown, M., Fan, S., Centola, M., Wu, C.-Y., Yamada, N., Gabalaway, H. E., O'Shea, J. J.Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.J. Immun. 164: 4659-4664, 2000. 2. Pang, Y. H., Zheng, C. Q., Yang, X. Z., Zhang, W. J.Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.Cell. Immunol. 248: 115-120, 2007. 3. Yap, W.-H., Yeoh, E., Tay, A., Brenner, S., Venkatesh, B.STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.FEBS Lett. 579: 4470-4478, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

86 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Signal transducer and activator of transcription 4

Subcellular Location

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Sequence Similarities

Belongs to the transcription factor STAT family.

Protein Name

Signal transducer and activator of transcription 4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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