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Anti-MCM5 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

MCM5 (MINICHROMOSOME MAINTENANCE, S. CEREVISIAE, HOMOLOG OF, 5), also known as CDC46, is a protein that in humans is encoded by the MCM5 gene. MCM5 is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. And MCM5 is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The MCM5 gene is mapped on 22q12.3. The MCM5 gene contains 16 exons. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.

Synonyms

DNA replication licensing factor MCM5;3.6.4.12; CDC46 homolog; P1-CDC46; MCM5; CDC46

Gene Name

MCM5

Gene ID

4174

UniProt

P33992

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MCM5, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Heart, liver, duodenum, blood vessels and kidney.

Applications

Flow Cytometry

Field of Research

DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity) . Interacts with MCMBP. .

References & Citations

1. Burkhart, R., Schulte, D., Hu, D., Musahl, C., Gohring, F., Knippers, R. Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. Europ. J. Biochem. 228: 431-438, 1995. 2. Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., Almouzni, G. Regulation of replication fork progression through histone supply and demand. Science 318: 1928-1931, 2007. 3. Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996) . Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5. Cytogenet Cell Genet 73 (4) : 317–21.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

82286 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

DNA replication licensing factor MCM5

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the MCM family.

Protein Name

DNA replication licensing factor MCM5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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