Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Kallistatin/SERPINA4 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PA1638-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Serpina 4, also called Kallistatin, PI4 or TISSUE KALLIKREIN INHIBITOR, is a protein that in humans is encoded by the SERPINA4 gene. The serpina4 is a member of the serpin superfamily and represents a major inhibitor of human tissue kallikrein in the circulation. The SERPINA4 gene is localized to 14q32.13. The translated amino acid sequence of serpina4 matches the protein sequence and shares 44 to 46% sequence identity with other serpin family members. Kallistatin is a serine proteinase inhibitor (serpin) and a heparin-binding protein. It is localized in vascular smooth muscle cells and endothelial cells of blood vessels, suggesting that it may be involved in the regulation of vascular function. And serpina4 also plays a role in neointima hyperplasia.

Synonyms

Kallistatin; Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4; SERPINA4; KST, PI4

Gene Name

SERPINA4

Gene ID

5267

UniProt

P29622

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Kallistatin.

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Invasion/Microenvironment, Protease Inhibitors, Proteolysis/Ubiquitin, Serum Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. .

References & Citations

1. Chai, K. X., Chen, L.-M., Chao, J., Chao, L. Kallistatin: a novel human serine proteinase inhibitor: molecular cloning, tissue distribution, and expression in Escherichia coli. J. Biol. Chem. 268: 24498-24505, 1993. 2. Chai, K. X., Ward, D. C., Chao, J., Chao, L. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4) . Genomics 23: 370-378, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

48542 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Kallistatin

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the serpin family.

Protein Name

Kallistatin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD8 (C8/468 + C8/144B), CF405S conjugate, 0.1mg/mL
BNC040750-100 1x 100 µL

CD8 (C8/468 + C8/144B), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
N-Cadherin / Cadherin-2 / CD325 (NCAD) (CDH2/1573), CF640R conjugate, 0.1mg/mL
BNC401573-500 1x 500 µL

N-Cadherin / Cadherin-2 / CD325 (NCAD) (CDH2/1573), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561), CF740 conjugate, 0.1mg/mL
BNC742561-500 1x 500 µL

NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
CD31 / PECAM-1 (Endothelial Cell Marker) (C31/1395R), CF405S conjugate, 0.1mg/mL
BNC041395-500 1x 500 µL

CD31 / PECAM-1 (Endothelial Cell Marker) (C31/1395R), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Squamous Cell Carcinoma Antigen 1 (CPTC-SERPINB3-2), CF488A conjugate, 0.1mg/mL
BNC882250-500 1x 500 µL

Squamous Cell Carcinoma Antigen 1 (CPTC-SERPINB3-2), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details
CD56 / NCAM (NCAM1/784), 0.2mg/mL
BNUB0784-500 1x 500 µL

CD56 / NCAM (NCAM1/784), 0.2mg/mL

Sign In for Pricing
View Details