What sizes are available for Anti-Kallikrein 2/KLK2 Antibody Picoband® Fluoro488 Conjugated?

Anti-Kallikrein 2/KLK2 Antibody Picoband® Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

Anti-Kallikrein 2/KLK2 Antibody Picoband® Fluoro488 Conjugated

Q: What is the catalog number for Anti-Kallikrein 2/KLK2 Antibody Picoband® Fluoro488 Conjugated?

The catalog number for Anti-Kallikrein 2/KLK2 Antibody Picoband® Fluoro488 Conjugated is PA1626-Fluoro488.

Selected Variant

PA1626-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

KLK2 (KALLIKREIN 2), also called GLANDULAR or PROSTATIC, is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. The KLK2 is a member of glandular kallikrein gene family that comprises 25 to 30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides. The KLK2 gene is mapped to 19q13.33. And the KLK2 gene contains 5 exons. An alternative KLK2 transcript, which they call KLK2-linked molecule (KLM), that arises from the use of an alternate donor site within intron 1. KLM shares only the N-terminal 15-amino acid signal peptide with the original KLK2 protein; the mature proteins display no similarity.

Synonyms

Kallikrein-2;3.4.21.35; Glandular kallikrein-1; hGK-1; Tissue kallikrein-2; KLK2

Gene Name

KLK2

Gene ID

3817

UniProt

P20151

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 2.

Clonality

Polyclonal

Tissue Specificity

Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

References & Citations

1. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130, 2000. 2. Mason, A. J., Evans, B. A., Cox, D. R., Shine, J., Richards, R. I. Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature 303: 300-307, 1983. 3. Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, Trapman J (May 1989) . The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

28671 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Kallikrein-2

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Sequence Similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein Name

Kallikrein-2

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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