What sizes are available for Anti-Kallikrein 1/KLK1 Antibody Picoband® Fluoro647 Conjugated?

Anti-Kallikrein 1/KLK1 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

Anti-Kallikrein 1/KLK1 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-Kallikrein 1/KLK1 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-Kallikrein 1/KLK1 Antibody Picoband® Fluoro647 Conjugated is PA1625-Fluoro647.

Selected Variant

PA1625-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

KLK1 (KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.

Synonyms

Kallikrein-1;3.4.21.35; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein; KLK1

Gene Name

KLK1

Gene ID

3816

UniProt

P06870

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Kallikrein 1.

Clonality

Polyclonal

Tissue Specificity

Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. .

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Serum Proteins, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

References & Citations

1. Azizi, M., Boutouyrie, P., Bissery, A., Agharazii, M., Verbeke, F., Stern, N., Bura-Riviere, A., Laurent, S., Alhenc-Gelas, F., Jeunemaitre, X. Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans. J. Clin. Invest. 115: 780-787, 2005. 2. Baker, A. R., Shine, J. Human kidney kallikrein: cDNA cloning and sequence analysis. DNA 4: 445-450, 1985. 3. Clements J, Hooper J, Dong Y, Harvey T (2001) . The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

28890 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Kallikrein-1

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Sequence Similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein Name

Kallikrein-1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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