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Anti-IL3RA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

IL3RA (INTERLEUKIN 3 RECEPTOR, ALPHA), also called CD123 (Cluster of Differentiation 123), is a human gene. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The IL3RA is mapped on Xp22.33. The genomic structures of IL3RA and CSF2RA are very similar and share an additional exon encoding part of the C-terminal domain not found in other members of this gene family. As in human hematopoietic cells, IL3 and GMCSF competed for binding in fibroblasts expressing the cDNAs for IL3RA, CSF2RA, and the common beta subunit, indicating that different alpha subunits compete for a common beta subunit.

Synonyms

Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123; IL3RA; IL3R

Gene Name

IL3RA

Gene ID

3563

UniProt

P26951

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human IL3RA.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Adapters, Cytokines, Immunology, Innate Immunity, Interleukins, Signal Transduction, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

This is a receptor for interleukin-3.

References & Citations

1. Itoh, N., Yonehara, S., Schreurs, J., Gorman, D. M., Maruyama, K., Ishii, A., Yahara, I., Arai, K., Miyajima, A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science 247: 324-327, 1990. 2. Kitamura, T., Sato, N., Arai, K., Miyajima, A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta-subunit for the human IL-3 and GM-CSF receptors. Cell 66: 1165-1174, 1991.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

43330 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin-3 receptor subunit alpha

Subcellular Location

Membrane; Single-pass type I membrane protein.

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Protein Name

Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha/IL-3R subunit alpha/IL-3R-alpha/IL-3RA)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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