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Anti-Homeobox protein Hox-A4 HOXA4 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PA1603-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

HOXA4 (HOMEOBOX A4), also known as HOX1D or HOMOLOG OF, is a protein that in humans is encoded by the HOXA4 gene, which is also part of the A cluster on chromosome 7. HOXA4 encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Its cytogenetic location is 7q15.2. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development.

Synonyms

Homeobox protein Hox-A4; Homeobox protein Hox-1.4; Homeobox protein Hox-1D; HOXA4; HOX1D

Gene Name

HOXA4

Gene ID

3201

UniProt

Q00056

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HOXA4, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Embryonic nervous system.

Applications

Flow Cytometry

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT- 3'.

References & Citations

1. McAlpine PJ, Shows TB (July 1990) . Nomenclature for human homeobox genes. 2. Scott MP (November 1992) . Vertebrate homeobox gene nomenclature. 3. Entrez Gene: HOXA4 homeobox A4.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

34499 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein Hox-A4

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Protein Name

Homeobox protein Hox-A4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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