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Anti-Homeobox protein Hox-A3 HOXA3 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PA1602-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

HOXA3 (HOMEOBOX A3) is a protein that in humans is encoded by the HOXA3 gene, which is also part of the A cluster on chromosome 7. HOXA3 encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Its cytogenetic location is 7q15.2. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA3 protein is able to complement Hoxd3 deficiency when expressed in the context of the Hoxd3 allele.

Synonyms

Homeobox protein Hox-A3; Homeobox protein Hox-1E; HOXA3; HOX1E

Gene Name

HOXA3

Gene ID

3200

UniProt

O43365

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human HOXA3, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

Flow Cytometry

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

References & Citations

1. Greer, J. M., Puetz, J., Thomas, K. R., Capecchi, M. R. Maintenance of functional equivalence during paralogous Hox gene evolution. Nature 403: 661-665, 2000. 2. McAlpine PJ, Shows TB (Aug 1990) . Nomenclature for human homeobox genes. 3. Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007) . DNA methylation regulates MicroRNA expression.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

46369 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein Hox-A3

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the Antp homeobox family.

Protein Name

Homeobox protein Hox-A3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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