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Anti-HDJ2/DNAJA1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

DNAJA1 (DnaJ homolog subfamily A member 1), also called DJA1, HSDJ, HSPF4, is a protein that in humans is encoded by the DNAJA1 gene. The deduced 397-amino acid DNAJA1 protein is 32% identical to E. coli DnaJ, with the highest identity in the N-terminal region. Among the known DNAJ homologs in S. cerevisiae, DNAJA1 is most identical to YDJ1, which may be involved in the transport of certain proteins into the mitochondria and endoplasmic reticulum. Dja1 is expressed in mouse testis and prostate by immunohistochemical analysis and Western blot analysis. Transplantation experiments with fluorescence-tagged spermatogonia into Dja1 -/- mice revealed a primary defect of Sertoli cells in maintaining spermiogenesis at steps 8 and 9.

Synonyms

DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; HSDJ; Heat shock 40 kDa protein 4; Heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2; DNAJA1; DNAJ2, HDJ2, HSJ2, HSPF4

Gene Name

DNAJA1

Gene ID

3301

UniProt

P31689

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human HDJ2, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. .

Applications

Flow Cytometry

Field of Research

Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573) . Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877) . Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510) . Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202) . .

References & Citations

1. Chellaiah, A., Davis, A., Mohanakumar, T. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. Biochim. Biophys. Acta 1174: 111-113, 1993. 2. Banasavadi-Siddegowda YK et al. FKBP38 Peptidylprolyl Isomerase Promotes the Folding of Cystic Fibrosis Transmembrane Conductance Regulator in the Endoplasmic Reticulum. J Biol Chem 286:43071-80 (2011) . 3. Chellaiah A, Davis A, Mohanakumar T (Aug 1993) . Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. Biochim Biophys Acta 1174 (1) : 111–3.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

44868 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

DnaJ homolog subfamily A member 1

Subcellular Location

Membrane ; Lipid-anchor . Cytoplasm . Microsome . Nucleus . Cytoplasm, perinuclear region . Mitochondrion . Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity) . Primarily cytoplasmic. A minor proportion is associated with nuclei. .

Sequence Similarities

Contains 1 CR-type zinc finger.

Protein Name

DnaJ homolog subfamily A member 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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