Anti-Forkhead box protein P1 FOXP1 Antibody Picoband® Fluoro488 Conjugated

FOXP1 (forkhead box P1) is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene (s) . Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell (ESC) -specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs (2) .

Transcriptional repressor (PubMed:18347093) . Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity) . Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T (FH) s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity) . Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198) . Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093) . Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716) . Can negatively regulate androgen receptor signaling (PubMed:18640093) . .

1. Banham, A. H., Beasley, N., Campo, E., Fernandez, P. L., Fidler, C., Gatter, K., Jones, M., Mason, D. Y., Prime, J. E., Trougouboff, P., Wood, K., Cordell, J. L.The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.Cancer Res. 61: 8820-8829, 2001. 2. Feng, X., Ippolito, G. C., Tian, L., Wiehagen, K., Oh, S., Sambandam, A., Willen, J., Bunte, R. M., Maika, S. D., Harriss, J. V., Caton, A. J., Bhandoola, A., Tucker, P. W., Hu, H.Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Blood 115: 510-518, 2010. 3. Shi, C., Sakuma, M., Mooroka, T., Liscoe, A., Gao, H., Croce, K. J., Sharma, A., Kaplan, D., Greaves, D. R., Wang, Y., Simon, D. I.Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.Blood 112: 4699-4711, 2008.