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Anti-GABA A Receptor alpha 1/GABRA1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

GABRA1, Gamma-aminobutyric acid receptor subunit alpha-1, is a protein that in humans is encoded by the GABRA1 gene. The 1,055-bp GABRA1 clone contained an open reading frame and 260 nucleotides in the 5-prime noncoding region. The 351-amino acid sequence shows 97% homology with its bovine counterpart. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-1; GABA (A) receptor subunit alpha-1; GABRA1

Gene Name

GABRA1

Gene ID

2554

UniProt

P14867

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human GABA A Receptor alpha 1, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

Flow Cytometry

Field of Research

Amino Acids, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitter, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity) . .

References & Citations

1. Cossette, P., Liu, L., Brisebois, K., Dong, H., Lortie, A., Vanasse, M., Saint-Hilaire, J.-M., Carmant, L., Verner, A., Lu, W.-Y., Wang, Y. T., Rouleau, G. A.Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy.Nature Genet. 31: 184-189, 2002. 2. Kralic, J. E., Criswell, H. E., Osterman, J. L., O'Buckley, T. K., Wilkie, M. E., Matthews, D. B., Hamre, K., Breese, G. R., Homanics, G. E., Morrow, A. L.Genetic essential tremor in gamma-aminobutyric acid-A receptor alpha-1 subunit knockout mice.J. Clin. Invest. 115: 774-779, 2005. 3. Rudolph, U., Crestani, F., Benke, D., Brunig, I., Benson, J. A., Fritschy, J.-M., Martin, J. R., Bluethmann, H., Mohler, H.Benzodiazepine actions mediated by specific gamma-aminobutyric acid-A receptor subtypes.Nature 401: 796-800, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51802 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Gamma-aminobutyric acid receptor subunit alpha-1

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.

Protein Name

Gamma-aminobutyric acid receptor subunit alpha-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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