Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Ectodysplasin-A EDA Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Anhidrotic ectodermal dysplasia (EDA) is an X-linked recessive disorder which affects ectodermal structures. Ectodysplasin-A, the protein encoded by the EDA gene, is a member of the tumor necrosis factor ligand superfamily that forms a collagen triple helix, suggesting functions in signal transduction and cell adhesion. Wnt signaling does control EDA gene expression, but ectodysplasin-A does not feedback on the Wnt pathway.

Synonyms

Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein; Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form; EDA; ED1, EDA2

Gene Name

EDA

Gene ID

1896

UniProt

Q92838

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human EDA, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. .

Applications

Flow Cytometry

Field of Research

Developmental Biology, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.

References & Citations

1. Bayes, M., Hartung, A. J., Ezer, S., Pispa, J., Thesleff, I., Srivastava, A. K., Kere, J. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Molec. Genet. 7: 1661-1669, 1998. 2. Durmowicz, M. C., Cui, C.-Y., Schlessinger, D. The EDA gene is a target of, but does not regulate Wnt signaling. Gene 285: 203-211, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41294 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ectodysplasin-A

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Protein Name

Ectodysplasin-A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Dis3l (NM_001008380) Rat Tagged Lenti ORF Clone
RR213833L4 10 µg

Dis3l (NM_001008380) Rat Tagged Lenti ORF Clone

Ask
View Details
FUT8 Antibody (Center) [AMM04651G]
AMM04651G-01 50 µL

FUT8 Antibody (Center) [AMM04651G]

Ask
View Details
FUT8 Antibody (Center) [AMM04651G]
AMM04651G-02 100 µL

FUT8 Antibody (Center) [AMM04651G]

Ask
View Details
FUT8 Antibody (Center) [AMM04651G]
AMM04651G-03 200 µL

FUT8 Antibody (Center) [AMM04651G]

Ask
View Details
FUT8 Antibody (Center) [AMM04651G]
AMM04651G-04 400 µL

FUT8 Antibody (Center) [AMM04651G]

Ask
View Details
GKAP
523326-01 100 µL

GKAP

Ask
View Details