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Anti-Desmoglein 2/DSG2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

Synonyms

Desmoglein-2; Cadherin family member 5; HDGC; DSG2; CDHF5

Gene Name

DSG2

Gene ID

1829

UniProt

Q14126

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 2, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

All of the tissues tested and carcinomas.

Applications

Flow Cytometry

Field of Research

Cadherins, Cancer, Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

References & Citations

1. Arnemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992) . The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18. Genomics 13 (2) : 484–6. 2. Entrez Gene: DSG2 desmoglein 2. mutations in DSG2 contribute to the development of ARVD/C. 3. Syrris, P., Ward, D., Asimaki, A., Evans, A., Sen-Chowdhry, S., Hughes, S. E., McKenna, W. J. Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease. Europ. Heart J. 28: 581-588, 2007.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

122294 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Desmoglein-2

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Sequence Similarities

Contains 4 cadherin domains.

Protein Name

Desmoglein-2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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