Anti-Desmoglein 2/DSG2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
Synonyms
Desmoglein-2; Cadherin family member 5; HDGC; DSG2; CDHF5
Gene Name
DSG2
Gene ID
1829
UniProt
Q14126
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 2, different from the related mouse and rat sequences by one amino acid.
Clonality
Polyclonal
Tissue Specificity
All of the tissues tested and carcinomas.
Applications
Flow Cytometry
Field of Research
Cadherins, Cancer, Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
References & Citations
1. Arnemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992) . The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18. Genomics 13 (2) : 484–6. 2. Entrez Gene: DSG2 desmoglein 2. mutations in DSG2 contribute to the development of ARVD/C. 3. Syrris, P., Ward, D., Asimaki, A., Evans, A., Sen-Chowdhry, S., Hughes, S. E., McKenna, W. J. Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease. Europ. Heart J. 28: 581-588, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
122294 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Desmoglein-2
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Sequence Similarities
Contains 4 cadherin domains.
Protein Name
Desmoglein-2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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