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Anti-CD89/FCAR Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

FCAR, Receptor for Fc fragment of IGA, is also known as CD89. Human Fc-alpha receptor (FCAR) is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types. FCAR is mapped to 19q13.4. Human COS cells transfected with FCAR cDNA bind to IgA, but not IgG.

Synonyms

Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89; FCAR; CD89

Gene Name

FCAR

Gene ID

2204

UniProt

P24071

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle of human CD89.

Clonality

Polyclonal

Tissue Specificity

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. .

Applications

Flow Cytometry

Field of Research

Cell Type Markers, Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. .

References & Citations

1. Kremer, E. J., Kalatzis, V., Baker, E., Callen, D. F., Sutherland, G. R., Maliszewski, C. R.The gene for the human IgA Fc receptor maps to 19q13.4.Hum. Genet. 89: 107-108, 1992. 2. Maliszewski, C. R., March, C. J., Schoenborn, M. A., Gimpel, S., Shen, L.Expression cloning of a human Fc receptor for IgA.J. Exp. Med. 172: 1665-1672, 1990.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

32265 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Immunoglobulin alpha Fc receptor

Subcellular Location

Isoform A.1: Cell membrane; Single-pass type I membrane protein.

Protein Name

Immunoglobulin alpha Fc receptor (IgA Fc receptor)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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