Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband® Fluoro647 Conjugated is PA1517-Fluoro647.

Selected Variant

PA1517-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

CCR4, C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194) . The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Synonyms

C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; CD194; Ccr4; Cmkbr4

Gene Name

CCR4

Gene ID

12773

UniProt

P51680

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse CCR4, identical to the related rat sequence.

Clonality

Polyclonal

Tissue Specificity

Expressed in the thymus, macrophages and T- and B-cells.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS) -induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. .

References & Citations

1. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O.The T cell-ed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.J. Biol. Chem. 272: 15036-15042, 1997. 2. Imai, T., Chantry, D., Raport, C. J., Woods, C. L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W.Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.J. Biol. Chem. 273: 1764-1768, 1998. 3. Oo, Y. H., Weston, C. J., Lalor, P. F., Curbishley, S. M., Withers, D. R., Reynolds, G. M., Shetty, S., Harki, J., Shaw, J. C., Eksteen, B., Hubscher, S. G., Walker, L. S. K., Adams, D. H.Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.J. Immun. 184: 2886-2898, 2010.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41408 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

C-C chemokine receptor type 4

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein Name

C-C chemokine receptor type 4 (C-C CKR-4/CC-CKR-4/CCR-4/CCR4)

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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