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Anti-Aquaporin 8/AQP8 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PA1511-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

AQP8, also known as Aquaporin-8, is a protein that in humans is encoded by the AQP8 gene. Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0) . Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. The AQP8 gene contains 6 exons. It is mapped to chromosome 16p12. Northern blot analysis of human tissues detected a 1.35-kb AQP8 mRNA only in pancreas and colon.

Synonyms

Aquaporin-8; AQP-8; AQP8

Gene Name

AQP8

Gene ID

343

UniProt

O94778

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Aquaporin 8.

Clonality

Polyclonal

Tissue Specificity

Expressed only in pancreas and colon.

Applications

Flow Cytometry

Field of Research

Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.

References & Citations

1. Huang J, et al. Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. Zhonghua Fu Chan Ke Za Zhi, 2009 Jan. 2. Larocca MC, et al. Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport. Am J Physiol Gastrointest Liver Physiol, 2009 Jan. 3. Zhu X, et al. The expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta in term pregnancies complicated by idiopathic polyhydramnios. Early Hum Dev, 2010 Oct.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

27381 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Aquaporin-8

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the annexin family.

Protein Name

Aquaporin-8 (AQP-8)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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