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Anti-MEKK2/MAP3K2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase (MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the International Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.

Synonyms

Mitogen-activated protein kinase kinase kinase 2;2.7.11.25; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; MAP3K2; MAPKKK2, MEKK2

Gene Name

MAP3K2

Gene ID

10746

UniProt

Q9Y2U5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK2, different from the related rat and mouse sequences by one amino acid.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity) . Plays a role in caveolae kiss-and-run dynamics. .

References & Citations

1. Yao Z, et al. Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One, 2010 Sep 7. 2. Cazares LH, et al. Maging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. Clin Cancer Res, 2009 Sep 1.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

69741 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Mitogen-activated protein kinase kinase kinase 2

Subcellular Location

Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.

Sequence Similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Protein Name

Mitogen-activated protein kinase kinase kinase 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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