Anti-AIMP2/p38 Antibody Picoband® Fluoro488 Conjugated

AIMP2, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, also known as AIMP2, is an enzyme that in humans is encoded by the AIMP2 gene. AIMP2 encodes a predicted 312-amino acid protein. The AIMP2 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. AIMP2 and HRI overlap slightly and are arranged in a tail-to-tail fashion. AIMP2 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. AIMP2 is transcribed in the opposite ion compared to HRI and PMS2. AIMP2 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex. AIMP2 can work as a mediator of TGF-beta signaling and its functional importance in the control of MYC during lung differentiation.

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1; AIMP2; JTV1; PRO0992

A synthetic peptide corresponding to a sequence in the middle region of human AIMP2/p38, different from the related rat and mouse sequences by three amino acids.

Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. .

1. Corti, O., Hampe, C., Koutnikova, H., Darios, F., Jacquier, S., Prigent, A., Robinson, J.-C., Pradier, L., Ruberg, M., Mirande, M., Hirsch, E., Rooney, T., Fournier, A., Brice, A.The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.Hum. Molec. Genet. 12: 1427-1437, 2003. 2. Kim, M. J., Park, B.-J., Kang, Y.-S., Kim, H. J., Park, J.-H., Kang, J. W., Lee, S. W., Han, J. M., Lee, H.-W., Kim, S.Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.Nature Genet. 34: 330-336, 2003. 3. Nicolaides, N. C., Kinzler, K. W., Vogelstein, B.Analysis of the 5-prime region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene.Genomics 29: 329-334, 1995.

Cytoplasm, cytosol . Nucleus . Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. .