Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ADAMTS4/ADAMTS4 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; ADAMTS-4;3.4.24.82; ADMP-1; Aggrecanase-1; ADAMTS4; KIAA0688; UNQ769/PRO1563

Gene Name

ADAMTS4

Gene ID

9507

UniProt

O75173

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ADAMTS4, different from the related rat and mouse sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

References & Citations

1. Hurskainen, T. L., Hirohata, S., Seldin, M. F., Apte, S. S.ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: general features and genomic distribution of the ADAM-TS family.J. Biol. Chem. 274: 25555-25563, 1999. 2. Tang, B. L., Hong, W.ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.FEBS Lett. 445: 223-225, 1999. 3. Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A., Copeland, R. A., Decicco, C. P., Wynn, R., Rockwell, A., Yang, F., and 16 others.Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.Science 284: 1664-1666, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

90197 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

A disintegrin and metalloproteinase with thrombospondin motifs 4

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Contains 1 disintegrin domain.

Protein Name

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4/ADAM-TS4/ADAMTS-4)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit Polyclonal FKBP12 Antibody [Alexa Fluor 594]
NBP2-41272AF594 0.1 mL

Rabbit Polyclonal FKBP12 Antibody [Alexa Fluor 594]

Ask
View Details
Magic™ Membrane Protein Human SDF2L1 (Stromal cell derived factor 2 like 1)
MP0295J Each

Magic™ Membrane Protein Human SDF2L1 (Stromal cell derived factor 2 like 1)

Ask
View Details
Gck (NM_001270850) Rat Tagged ORF Clone
RR216698 10 µg

Gck (NM_001270850) Rat Tagged ORF Clone

Ask
View Details
Human Epididymis Lysate Membrane Fraction
MBS8411141-01 0.1 mg

Human Epididymis Lysate Membrane Fraction

Ask
View Details
Human Epididymis Lysate Membrane Fraction
MBS8411141-02 5x 0.1 mg

Human Epididymis Lysate Membrane Fraction

Ask
View Details
Canine Glutamate carboxypeptidase 2 (FOLH1) ELISA Kit
MBS7231877-01 48 Well

Canine Glutamate carboxypeptidase 2 (FOLH1) ELISA Kit

Ask
View Details