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Anti-Resistin/RETN Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich protein that in humans is encoded by the RETN gene. The resistin gene comprises 4 exons, the first of which is untranslated, and spans approximately 1,750 bp. The human resistin gene is localized to a cloned fragment of human chromosome 19. In primates, pigs and dogs, resistin is secreted by immune and epithelial cells while in rodents, it is secreted by adipose tissue. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus.

Synonyms

Resistin; Adipose tissue-specific secretory factor; ADSF; Adipose-specific cysteine-rich secreted protein A12-alpha; Cysteine-rich secreted protein FIZZ3; Retn; Fizz3

Gene Name

RETN

Gene ID

57264

UniProt

Q99P87

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Resistin.

Clonality

Polyclonal

Tissue Specificity

Expressed in white but not brown adipose tissue in a variety of organs.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cardiovascular, Diabetes-associated, Energy Metabolism, Energy Transfer Pathways, Growth Factors/Hormones, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

References & Citations

1. Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A., Henzel, W., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., Frantz, G. D., Tumas, D. B., Peale, F. V., Jr., Shelton, D. L., Hebert, C. C.FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family.EMBO J. 19: 4046-4055, 2000. 2. Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., Lazar, M. A.The hormone resistin links obesity to diabetes.Nature 409: 307-312, 2001. 3. Wang, H., Chu, W. S., Hemphill, C., Elbein, S. C.Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians.J. Clin. Endocr. Metab. 87: 2520-2524, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

12492 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Resistin

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.

Protein Name

Resistin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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