Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IL23 P19/IL23A Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

IL-23, Interleukin-23, also known as Interleukin-23 subunit alphainin (IL23A), is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit) . The International Radiation Hybrid Mapping Consortium mapped the IL-23 gene to chromosome 12. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration.

Synonyms

Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19; Il23a

Gene Name

IL23A

Gene ID

83430

UniProt

Q9EQ14

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of mouse IL23 P19, different from the related rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Secreted by activated dendritic cells (at protein level) . Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages. .

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. .

References & Citations

1. Hu, W., Dehmel, T., Pirhonen, J., Hartung, H.-P., Kieseier, B. C.Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.Arch. Neurol. 63: 858-864, 2006. 2. Kullberg, M. C., Jankovic, D., Feng, C. G., Hue, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J., Powrie, F., Cheever, A. W., Maloy, K. J., Sher, A.IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.J. Exp. Med. 203: 2485-2494, 2006. 3. Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., Zonin, F., Vaisberg, E., and 13 others.Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.Immunity 13: 715-725, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

22071 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin-23 subunit alpha

Subcellular Location

Secreted . Secreted upon association with IL12B.

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein Name

Interleukin-23 subunit alpha (IL-23 subunit alpha/IL-23-A)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Mouse Midkine (MK) ELISA Kit
EKN47071 96 Tests

Mouse Midkine (MK) ELISA Kit

Sign In for Pricing
View Details
Rat Slc39a9 ELISA Kit
ELI-18871r 96 Tests

Rat Slc39a9 ELISA Kit

Sign In for Pricing
View Details
Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit
MBS2600459-01 48 Well

Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit

Sign In for Pricing
View Details
Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit
MBS2600459-02 96 Well

Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit

Sign In for Pricing
View Details
Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit
MBS2600459-03 5x 96 Well

Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit

Sign In for Pricing
View Details
Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit
MBS2600459-04 10x 96 Well

Rabbit Sex Hormone Binding Globulin (SHBG) ELISA Kit

Sign In for Pricing
View Details