Anti-Interleukin-7 IL7 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
IL-7, Interleukin 7, is a protein that in humans is encoded by the IL-7 gene. IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by lymphocytes. By the combination of approaches, IL-7 is located on 8q12-q13. IL-7 is critical for early T-cell development and homeostasis of naive and memory CD8-positive T cells. It signals through the IL-7 receptor complex, which consists of the IL7R-alpha chain and the common IL2R-gamma chain is critical for early T-cell development and homeostasis of naive and memory CD8 -positive T cells. It signals through the IL-7 receptor complex, which consists of the IL7R-alpha chain and the common IL2R-gamma chain.
Synonyms
Interleukin-7; IL-7; Il7; Il-7
Gene Name
IL7
Gene ID
16196
UniProt
P10168
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse IL7.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
References & Citations
1. Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE (January 1989) . Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc. Natl. Acad. Sci. U.S.A. 86 (1) : 302–6. 2. Lupton SD, Gimpel S, Jerzy R, et al. (1990) . Characterization of the human and murine IL-7 genes. J. Immunol. 144 (9) : 3592–601. 3. Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA (July 1989) . The gene for human interleukin 7 (IL7) is at 8q12-13. Hum. Genet. 82 (4) : 371–2.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
17727 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Interleukin-7
Subcellular Location
Secreted.
Protein Name
Interleukin-7 (IL-7)
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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